A technique for converting from intravenous drug self-administration to liquid reinforcement

Lignocaine: a new technique for intravenous administration.

Current practices of intravenous lignocaine administration may result in a significant drop in blood level between the peak serum level from the initial bolus and the subsequent steady state from the constant infusion. This can cause a significant interval when plasma lignocaine levels are less than therapeutic, and ventricular ectopy may occur. To eliminate this subtherapeutic interval, a new ...

Methods for Intravenous Self Administration in a Mouse Model

Animal models have been developed to study the reinforcing effects of drugs, including the intravenous self-administration (IVSA) paradigm. The advantages of using an IVSA paradigm to study the reinforcing properties of drugs of abuse such as cocaine include the fact that the drug is self-administered instead of experimenter-administered, the schedule of reinforcement can be altered, and accura...

On drug transport after intravenous administration

A mathematical model of a drug transport after rapid injection is given. It takes into account three processes: drug plasma protein binding in central compartment transport processes between the central compartment and the peripheral compartment elimination of a drug from the central compartment.

An Interface for Reducing Errors in Intravenous Drug Administration

Input errors occur with drug infusion pumps when nurses or technicians incorrectly input the prescribed therapy through the control panel. Such number copying tasks are cognitively and visually demanding, errors are easily introduced and the process is often perceived as laborious. Stressful working conditions and poorly designed control panels will further add to the chance of error. An altern...

A survey of intravenous drug administration by preregistration house officers.